Synthesis and antibacterial properties of 7-[2-(3-substituted-5-isoxazolyl)-2-methoxyiminoacetamido]cep halospora nic acid derivatives.
نویسندگان
چکیده
The synthesis of new 2-(3-substituted-5-isoxazolyl)-2-methoxyiminoacetic acids and their condensation derivatives with a suitable cephalosporanic nucleus, is reported. Their antibacterial properties were tested in vivo and in vitro also against beta-lactamase producer microorganisms; particularly the oral bioavailability of some of these new derivatives was studied.
منابع مشابه
STUDIES UN UKALLYACTIVE UliFMAJLUSrUKirM liS l liKS VIf. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-( 3-ISOXAZOLYL)OXYMETHYLCEPHALOSPORIN DERIVATIVES
The synthesis and biological activities of a series of 3-(isoxazol-3-yl)oxymethyl cephalosporins are described. 7[2-(2-Aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido] -3[ (isoxazol-3-yl)oxymethyl]-3-cephem-4-carboxylic acid (7a) showedpotent activity against both Gram-positive and Gram-negative bacteria including some /3-lactamase producing species. Its pivaloyloxymethyl ester provided a good u...
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An extensive study" of structure-activity relationships of 7,3-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]cephalosporins (1) and related compounds led to the selection of 7~-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1-methyl-I H-tetrazol-5-yl) thiomethyl] ceph-3-em-4carboxylic acid (1a), cefmenoxime, for further biological evaluations. These Compounds (1) were prepared bas...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 40 11 شماره
صفحات -
تاریخ انتشار 1987